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Lorazepam is a prescription medication in the benzodiazepine class, commonly used to treat anxiety disorders, acute agitation, panic symptoms, insomnia related to anxiety, and seizure activity. It is also frequently used in hospital settings for sedation before procedures. Lorazepam works by enhancing the effects of GABA, a neurotransmitter that calms the brain and nervous system, helping reduce anxiety, promote relaxation, and control seizures.

The appropriate dosage of lorazepam depends on the condition being treated, patient age, and response to therapy. For anxiety, typical adult doses range from 1 mg to 3 mg per day, divided into 2–3 doses. For insomnia due to anxiety, a single dose of 1 mg to 2 mg at bedtime may be prescribed. Injectable forms used for seizures or sedation are administered under strict medical supervision. Lorazepam should always be taken exactly as prescribed, and dose changes should only be made by a healthcare provider.

Common side effects of lorazepam include drowsiness, dizziness, fatigue, muscle weakness, confusion, and impaired coordination. Some individuals may experience memory problems, blurred vision, or headache. Serious side effects can include respiratory depression, severe sedation, mood changes, or hallucinations, which require immediate medical attention, especially in older adults.

There are important warnings associated with lorazepam use. It carries boxed warnings for dependence, abuse, and withdrawal reactions, which can be severe or life-threatening if the medication is stopped suddenly. Combining lorazepam with alcohol, opioids, or other central nervous system depressants significantly increases the risk of breathing problems, coma, or death. Lorazepam should be used cautiously in individuals with liver disease, respiratory disorders, or a history of substance abuse. Pregnant or breastfeeding individuals should only use lorazepam under close medical supervision, and regular monitoring is essential to ensure safe and effective use.