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Tramadol is a prescription pain medication classified as an opioid analgesic with additional effects on serotonin and norepinephrine in the brain. It is commonly used to treat moderate to moderately severe pain, such as pain after surgery, injury, or from certain chronic conditions. Tramadol works by altering how the brain perceives pain, making it effective for patients who do not respond well to non-opioid pain relievers.
Dosage of tramadol depends on the severity of pain, patient age, and medical history. For adults using immediate-release tramadol, the usual starting dose is 50–100 mg every 4–6 hours as needed, with a maximum daily dose of 400 mg. Extended-release (ER) formulations are typically started at 100 mg once daily, with gradual increases if necessary. Tramadol should be taken exactly as prescribed, and extended-release tablets should not be crushed or chewed, as this can increase the risk of overdose.
There are important warnings associated with tramadol use. It carries a risk of dependence, misuse, and addiction, even when taken as directed. Tramadol may cause respiratory depression, especially at high doses or when combined with alcohol, benzodiazepines, or other sedatives. Because tramadol affects serotonin levels, it can increase the risk of serotonin syndrome, particularly when used with antidepressants or other serotonergic drugs. It may also increase the risk of seizures, especially in individuals with a seizure disorder.
Common side effects of tramadol include nausea, vomiting, dizziness, drowsiness, constipation, and headache. Some patients may experience sweating, dry mouth, or itching. Serious side effects can include confusion, slow or difficult breathing, fainting, or irregular heartbeat. Patients should avoid driving or operating heavy machinery until they know how tramadol affects them and should seek immediate medical attention if symptoms of overdose or severe reactions occur.